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By Pinuccia Valagussa (auth.), Monica Castiglione, Martine J. Piccart (eds.)

Adjuvant therapy is run sooner than or as stick with as much as surgeries for breast melanoma. confirmed luck in utilizing scientific cures taking into consideration breast keeping methods or decreasing threat of prevalence. even supposing there was a lot growth in the direction of a remedy, together with the creation of recent certain cures, metastasizing melanoma continues to be hugely incurable.

"The adjuvant remedy of breast melanoma has turn into usual of care. A spectrum of biologic and prognostic elements are thought of prior to a healing process is applied. during this textual content top investigators within the box speak about present administration and important investigative issues."

Steven T. Rosen, M.D.
Series Editor

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Extra resources for Adjuvant Therapy for Breast Cancer

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J Clin Oncol. 1997;15:1916–22. 42. Gasparini G, Barbareschi M, Doglioni C, et al. Expression of bcl-2 protein predicts efficacy of adjuvant treatments in operable node-positive breast cancer. Clin Cancer Res. 1995;1:189–98. 43. Cardoso F, Paesmans M, Larsimont D, et al. Potential predictive value of Bcl-2 for response to tamoxifen in the adjuvant setting of node-positive breast cancer. Clin Breast Cancer. 2004;5:364–9. 44. Paik S, Shak S, Tang G, et al. A multigene assay to predict recurrence of tamoxifentreated, node-negative breast cancer.

Consortium IHGS. Finishing the euchromatic sequence of the human genome. Nature. 2004;431:931–45. 4. Sorlie T, Tibshirani R, Parker J, et al. Repeated observation of breast tumour subtypes in independent gene expression data sets. Proc Natl Acad Sci U S A. 2003;100:8418–23. 5. Farmer P, Bonnefoi H, Becette V, et al. Identification of molecular apocrine breast tumours by microarray analysis. Oncogene. 2005;24:4660–71. 6. Sorlie T, Wang Y, Xiao C, et al. Distinct molecular mechanisms underlying clinically relevant subtypes of breast cancer: Gene expression analyses across three different platforms.

Lancet. 2003;361(9369):1590–6. 29. Sotiriou C, Neo SY, McShane LM, Korn EL, Long PM, Jazaeri A, et al. Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc Natl Acad Sci U S A. 2003;100(18):10393–8. 30. Hu Z, Fan C, Oh DS, et al. The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics. 2006;7:96. 31. Osborne CK, Bardou V, Hopp TA, et al. Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer.

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