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By Vasken Dilsizian MD, Jagat Narula MD, DM, PhD (auth.)

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Relation between regional 201 TI activity and regional volume fraction of interstitial fibrosis. In comparative clinicopathologic studies, a significant inverse correlation is shown between the magnitude of 201 TI uptake after reinjection and regional volume fraction of collagen. 034 20 0 "" ~ E 10 11 12 13 40 60 80 Interstitial fibrosi , vol % by use of light microscopic morphometry. 01) between 201TI reinjection and regional volume fraction of interstitial fibrosis, B. Orange lines indicate 95% confidence limits for the regression line.

After oral glucose loading, the patient was injected with 10 mCi of FDG and 25 mCi of 99mTc-sestamibi at rest. Dual-isotope single acquisition SPECT was performed approximately 60 minutes later by positioning two 20% pulse-height analyzer windows symmetrically around the 140 keV photopeak of 99mTc and the 511 keV photopeak of FDG. The digital electronics of the camera permitted frame-byframe decay correction for short-lived FDG. Thus, two separate sets of slices mapping the 99mTc-sestamibi and FDG distribution were simultaneously obtained, resulting in one-to-one correspondence in spatial registration.

Moreover, in a nonrandomized, retrospective study with rest-redistribution 201Tl, survival and survival without myocardial infarction tended to be significantly higher in patients with chronic ischemic left ventricular dysfunction treated with coronary artery revascularization compared with those treated with medical therapy alone. B, Actuarial survival curve in 85 patients with evidence of myocardial viability by rest-redistribution 201Tl is shown; 38 patients underwent coronary artery revascularization and 47 patients were treated medically.

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