Download Autoimmune Bullous Diseases: Text and Review by Marcel F. Jonkman PDF

By Marcel F. Jonkman

​This e-book presents compulsory learn fabric on classes on autoimmune bullous illnesses. citizens and researchers in dermatology and adjoining disciplines can use the e-book as a short reference consultant whilst facing those sufferers. The publication comprises protocols and follows overseas guidelines.​ at the moment there's no quickly primer on Autoimmune Bullous illnesses for dermatologists who desire to study the subtleties of prognosis and administration of this staff of mucocutaneous ailments. in view that mucous membranes also are integrated the subsequent scientific disciplines should be too: oral drugs and stomatology, ENT, ophthalmology, gynaecology, gastro-enterology. the heart for Blistering illnesses in Groningen has equipped because the yr 2000 an annual path on Bullous illnesses for dermatologists and pathologists. the employees is chosen from the college. The path is interactive and problem-oriented. The proposed ebook could characterize the documented useful wisdom of the workers on those ailments. the data could be transparent and functional with examples and questions for self-assessment.

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Example text

In various cases also expression of IgA in addition to IgG can be demonstrated. Solely IgA deposition can be seen in linear IgA disease and IgA epidermolysis bullosa acquisita on the epidermal and dermal side, respectively. The sensitivity of salt-split skin in comparison with monkey esophagus for pemphigoid sera is comparable to that of monkey esophagus with a sensitivity between 70 and 80 %. For EBA, the sensitivity is around 40–50 % [6]. Specificity of salt-split skin is high for all types of autoimmune bullous diseases and ranges between 97 and 100 %.

Score 5 yes? no? Score 3 Mucosa erosions, blistersat entire area? yes? Score 10 yes? Score 1 no? 1 lesion? no? 2 or 3 lesions? yes? no? Score 5 skull erosions, blisters, new yes? lesions? no? Score 0 yes? Score 5 no? more than 3 lesions? yes? two lesions > 2 cm? Score 2 affacts whole skull? yes? Score 4 yes? Score 10 no? 2 quadrants? no? at least 1 lesion > 6 cm? no? 1 quadrant affected? yes? Score 1 Fig. 4 Pemphigus disease area index (PDAI) flow diagram yes? Score 2 no? 3 quadrants affected? yes?

No? 2 or 3 lesion? Score 5 yes? no? no? more than 3 lesions? Score 2 yes? 4 Bullous pemphigoid disease area index (BPDAI) Reprinted from Murrell et al. F. F. 1 mg/kg/day of prednisone (or the equivalent), minocycline ≤ 100 mg/day, doxycycline 100 mg/day, lymecycline 300 mg/day, topical corticosteroids once a day including fluticasone propionate suspension 400 μg/once a day, colchicine 500 μg/ day, Salazopyrin 1 g/day, sulfapyridine 500 mg/day, sulfamethoxypyridazine 500 mg/day, nicotinamide 500 mg/day The following doses or less: azathioprine (1 mg/kg/day) with normal thiopurine-s-methyltransferase level, mycophenolate mofetil 500 mg/day, mycophenolic acid 360 mg/day, methotrexate 5 mg/week, cyclosporine 1 mg/kg/day Refers to therapies given intermittently, for example, when rituximab is used for MMP or IVIG monthly Presence of transient new lesions that heal without scarring within 1 week while patient is receiving minimal therapy for at least 2 months The absence of new or established lesions or pruritus while patient is receiving minimal therapy for at least 2 months Presence of transient new lesions that heal within 1 week without treatment while patient is off all MMP therapy for at least 2 months Absence of new or established lesions or pruritus while patient is off all MMP therapy for at least 2 months Appearance of ≥3 new lesions a month (blisters, erosions) that do not heal within 1 week or extension of established lesions in patient who has achieved disease control Reprinted from Murrell et al.

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