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By Bennie I Osburn; Ronald D Schultz

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Res. 38, 1877-1879. Hoover, E. , McCullough, C. , and Griesemer, R. A. (1972). J. Natl. Cancer Inst. 48, 973-983. Hoover, E. , Perryman, L. , and Kociba, G. J. (1973). Cancer Res. 33, 145-152. Horowitz, S. , and Hong, R. (1977). Monogr. Allergy 10. Jacoby, R. , and Griesemer, R. A. (1970). Am. J. Vet. Res. 3 1 , 1825-1833. , and Greaves, M. F . (1971). Clin. Exp. Immunol. 9, 483-498. Jeffcott, L. B. (1972). Biol. Rev. Cambridge Philos. Soc. 47, 439-464. Jeffcott, L. B M (1974a). / . Comp. Pathol.

Cotter, S. , Hardy, W. , and Essex, M. (1975). J. Am. Vet. Med. Assoc. 166, 449-454. Crawford, T. , McGuire, T. G , Hallowell, A. L , and Macomber, L. E. (1978). Proc. Am. Assoc. Equine Pract. 23, 265-274. Dale, D. C , Ailing, D. , and Wolff, S. M. (1972). J. Clin. Invest. 51, 2197-2204. Davies, D. , and Duncan, J. R. (1974). Proc. Soc. Exp. Biol. Med. 145, 1372-1373. Deem, D. , Traver, D. , Thacker, H. , and Perryman, L. E. (1979). J. Am. Vet. Med. Assoc. 175 (in press). DeMartini, J. C. (1974).

C-HS is an inherited disorder of cattle, mink, cats, mice, killer whales, and man (reviewed in Prieur and Col­ lier, 1978). The clinical manifestations include partial oculocutaneous albinism, photophobia, hemorrhagic tendency, and increased suscepti- 42 LANCE E. PERRYMAN bility to bacterial infections. C-HS in cattle occurs in Herefords which are easily recognized by the dilution of coat color and the presence of large cytoplasmic granules within neutrophils and several other cell types (Padgett et al, 1964).

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