By Elsner, Peter
Due to the fact that epidermis varieties the interface among the human physique and the surroundings, its mechanical houses are very important in overall healthiness and illness. Bioengineering of the outside: epidermis Biomechanics supplies an intensive creation within the organic foundation of pores and skin biomechanics. It explains the non-invasive tools that let dimension of the mechanical homes of the surface targeting commercially on hand tools.
Written by means of the world over top specialists within the box of non-invasive dimension expertise of the surface, this quantity describes the anatomy, biochemistry, body structure, and pathology of dermis biomechanics. It explains intimately tips on how to degree pores and skin mechanic houses and the way to exploit those measurements within the improvement of gear and cosmetics
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Extra info for Bioengineering of the Skin: Skin Biomechanics, Volume V
Load was recorded and stress calculated by dividing of load by skin thickness measured from a skin fold obtained with calipers. Cycle 1,5, 10,20,25, and 30 were recorded with more rapid paper speed to facilitate the evaluation of modulus of elasticity and stress values. The modulus of elasticity was calculated from the upper section of the stress-strain curve. Stress values decreased after repeated loading approximately with the logarithm of the number of cycles. The area under the curve of 30 cycles was evaluated by computerized calculation according to Simpson's formula (Hiilte, 1915; Denkel, 1983; Vogel, 1988c).
Dehiscence of the wound resulted in a sudden drop of the registered load. For experiments of 3-week duration, skin strips were punched and tensile strength was tested as described for evaluation of tensile strength in normal skin. Changes of tensile strength of skin wounds following treatment with drugs is expressed as a percentage of vehicle-treated controls. The dose-dependent decrease found after immediate postoperative treatment and the dose-dependent increase found after treatment in prolonged experiments with corticosteroids serve as comparative parameters for new test compounds.
J0rgensen et ai. (1989) found a dose-dependent increase of mechanical strength in intact rat skin after treatment with biosynthetic human growth hormone. Andreassen et ai. (1981) studied the biomechanical properties of skin in rats with streptozotocininduced diabetes. An increased stiffness and strength were found: maximal stiffness was increased by 20% and the strain rate at maximum stress was decreased by 10%. Oxlund et ai. (1980) found that the stiffness of rat skin was increased in the early postpartum period.