Download Clinical Pharmacology in Psychiatry: From Molecular Studies by C. Braestrup, P. H. Andersen (auth.), Prof. Dr. Svein G. PDF

By C. Braestrup, P. H. Andersen (auth.), Prof. Dr. Svein G. Dahl, Prof. Dr. Lars F. Gram (eds.)

This quantity collects the invited lectures and a few chosen contributions provided on the fifth foreign assembly on scientific Pharmacology in Psychiatry, which used to be held 26-30 June 1988 on the college of Troms0, Norway. The 24 h of sunlight on the northernmost college on the earth al­ lowed for lengthy, friendly and effective classes. The name of the convention in addition to a few of the issues lined symbolize a continuation of 4 prior meetings, the 1st held in Chicago in 1979 and arranged through the past due Earl U sdin and associates. the sooner meetings were documented in scientific Pharmacology in Psychiatry, edited via E. Usdin (Elsevier, ny, 1981), medical Pharmacology in Psychiatry. Neuroleptic and Antidepressant examine, edited by way of E. Usdin, S. G. Dahl, L. F. Gram and o. Lingjrerde (Macmillan Publishers Ltd., London, 1981), medical Pharmacology in Psychiatry. Bridging the Experimental-Therapeutic hole, edited by way of LF. Gram, E. Usdin, S.G. Dahl, P. Kragh-Sorensen, P. L. Morselli and F. Sjoqvist (Macmillan Publishers Ltd., London, 1983), and medical Pharmacology in Psychiatry. Selectivity in Psychotropic Drug motion - delivers or difficulties? edited through S. G. Dahl, L.F. Gram, S.M. Paul and W.Z. Potter (Psychopharmacology sequence three, Springer, Heidelberg, 1987).

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1985; Bjerkenstedt et al. 1985). As summarized in Table 2, it appears instead that W. Z. Potter et al. 42 Table'2. Effects of antidepressants on monoamine metabolites in cerebrospinal fluid (CSF) Drug % Change 5-HlAA Study MHPG HVA Imipramine Desipramine Amitriptyline Nortriptyline -35 -37 -36 -25 -39 -49 -41 -36 + 7 -19 - 3 (not done) Clomipramine Zimelidine Citalopram -48 -39 -29 -33 -20 -11 +14 + 8 +15 Bowden et al. (1985) Potter et aI. (1985) Bowden et al. (1985) Asberg et al. (1973) Bertilsson et al.

Neuropharmacology 22:791-795 Forrest IS, Fox J, Green DE, Melikian AP, Serra MT (1974) Total excretion of 3H_ chlorpromazine in chronically dosed animals: balance sheet. In: Forrest IS, Carz CJ, Usdin E (eds) The phenotiazines and structurally related drugs. Raven, New York, pp 347-356 Frost 11, Wagner HN, Dannals RF, et al. (1985) Imaging opiate receptors in the human brain by positron tomography. J Comput Assist Tomogr 9:231-236 Gunnet JW, Moore KE (1988) Neuroleptics and neuroendocrine function.

2), as early as 3 days postwithdrawal in one patient. The time course and clinical correlates, if any, of this effect require further investigation. References Arnett CD, Fowler JS, Wolf AP, Shiue CY, McPherson DW (1985) 18F_N_ methylspiroperidol: the radioligand of choice for PET studies of the dopamine receptor inhuman brain. Life Sci 36:1359-1366 Bagdy G, Perenyi A, Frecska E, Revai K, Pappa Z, Fekete MIK, Arato M (1985) Decrease in dopantine, its metabolites, and noradrenaline in cerebrospinal fluid of schizophrenic patients after withdrawal of long-term neuroleptic treatment.

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