Download Concepts, Clinical Developments, and Therapeutic Advances in by Kurt W. Kohn (auth.), F. M. Muggia (eds.) PDF

By Kurt W. Kohn (auth.), F. M. Muggia (eds.)

Where do you start to seem for a contemporary, authoritative article at the analysis or administration of a specific malignancy? The few basic oncology textbooks are typically old-fashioned. unmarried papers in really good journals are informative yet seldom entire; those are extra usually initial stories on a truly restricted variety of sufferers. definite normal journals often submit stable indepth stories of melanoma themes, and released symposium lectures are usually the simplest overviews to be had. Unfor­ tunately, those stories and supplementations look sporadically, and the reader can by no means make sure while a subject matter of particular curiosity should be lined. melanoma remedy and study is a sequence of authoritative volumes which goal to satisfy this want. it truly is an try to identify a severe mass of oncology literature overlaying almost all oncology subject matters, revised often to maintain the insurance modern, simply on hand on a unmarried library shelf or by means of a unmarried own subscription. we've got approached the matter within the following model. First, by way of dividing the oncology literature into particular subdivisions reminiscent of lung can­ cer, genitourinary melanoma, pediatric oncology, and so on. moment, through asking emi­ nent experts in each one of those parts to edit a quantity at the particular subject on an annual or biannual foundation. each one subject and tumor kind is roofed in a quantity showing often and predictably, discussing present analysis, staging, markers, all sorts of therapy modalities, simple biology, and more.

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The trans-Pt(I1) complex, in fact, is an excellent means of producing high frequencies of DNA-protein crosslinks, and cells can repair these lesions effectively. The low cytotoxicity of trans-Pt(I1) argues against DNA-protein crosslinks per se as the major source of cisplatin cytotoxicity. Cisplatin cytotoxicity has been found in several, but not all, studies to correlate with interstrand crosslinking. Although cisplatin interstrand crosslinks may be potentially lethal, crosslinks between neighboring guanines in the same strand are more frequent cisplatin products and may be the more prominent contributors to cell killing [51].

Filipski J, Yin J, and Kohn KW: Reconstitution of intercalator-induced DNA scission by an active component from nuclear extracts. Biochim Biophs Acta 741: 116-122, 1983. Chen GL, Yang L, Rowe TC, Halligan BD, Tewey KM, and Liu LF: Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J Bioi Chern 259: 13560-13566, 1984. Nelson EM, Tewey KM, and Liu F: Mechanism of antitumor drug action: Poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-manisidide.

VP-16). The results indicate that an alteration in PASB, probably reflecting an altered topoisomerase response, can contribute to drug resistance. Conclusion The DNA filter elution techniques can be used to measure several types of DNA damage in mammalian cells, including single- and double-strand breaks, alkali-labile sites, interstrand crosslinks, and DNA-protein crosslinks. The assays are often sensitive enough to measure the effects of DNAdamaging anticancer drugs in the pharmacologic dose range.

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