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By E. Debus, C.J. Grossmann, A.P. Hubbuch, H.N. Lanners, R. Linke, Perkin

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Response of variant hereditary angioedema phenotypes to danazol therapy: genetic implications. J Clin Invest, 64, 280 (1979) 133. : Coccidioidomycosis complicating pregnancy. Obst Gynec, 28, 401 (1966) 134. Drutz, D. , McGuire, W. : Human sex hormones stimulate the growth and maturation of coccidioides immitus. Inf Immunity, 32, 897 (1981) 135. : Coccidioidomycosis. Am Review of Resp Dis, 117, 727 (1978) 136. , Powell, R. : Experimental pneumocystis carinii infection in nude and steroid treated normal mice : Proceedings of the Third International Workshop in Nude: 123 (1982) 137.

Russo, R. : Survival of skin homografts in uteri of pregnant progesteroneestrogen treated rats. Proc Soc Exp Bioi Med 128, I (1968) 207. Anderson, J. : Transplantation - nature's success. Lancet 2, 1077 (November 3) (1971;1 208. Anderson, J. : Studies of artificial immunological inertia. In: Anderson, J. M. ). The Biology and Surgery of Tissue Transplantation, Oxford Press, London, p 129 (1970) 209. Simmons, R. , Price, A. , Ozerkis, A. : The immunologic problem of pregnancy. V. The effect of estrogen and progesterone on allograft survival.

According to this scheme (Fig. 6) negative feedback of cortisol (corticosterone in rats) at the level of the hypothalamus-pituitary reduces the amount of ACTH released and subsequently decreases the amount of glucocorticoids secreted by the adrenal cortex. The glucocorticoid also depresses thymic function resulting in a decrease in thymic weight and possibly a reduction in thymosin secretion. Decreasing thymosin should conceivably reduce T -lymphocyte function and furthermore glucocorticoids can exort a direct influence on T -lymphocytes via glucocorticoid receptors.

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