By Prof. Kian Fan Chung, John G. Widdicombe, Homer A. Boushey
Cough is the main primary symptom of respiration ailment, and an issue which basic practitioners needs to take care of every day. This well timed quantity attracts jointly a wealth of modern learn into the mechanisms, pharmacology and treatments for cough, and locations those in medical context. The textual content comprises instructions at the commonest reasons of cough, discusses remedies and pitfalls in administration, summarizes present study on body structure, pharmacology and therapy of cough, and provides functional suggestion on analysis and administration matters for the clinician.
Cough: reasons, Mechanisms and treatment is the main finished, updated account of the topic. it's going to replace scientific and uncomplicated clinical scientists, and advertise destiny study. Readers are inspired to enforce the medical implications of the dialogue into regimen perform. This quantity will entice all these considering the therapy of respiration ailment, fairly these in health facility respiration devices, and also will be of use to basic practitioners.
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Additional info for Cough: Causes, Mechanisms and Therapy
NO Chest radiograph Spirometry + reversibility testing (hospital setting) Home PEF recording (general practice or spirometry unavailable) Any obvious primary pulmonary pathology? YES Manage according to treatment guidelines NO Is patient currently taking any therapy for cough? YES Stop therapy Cough worse Cough still present NO Cough persists Cough resolved Diagnostic testing/Empirical therapy Reintroduce therapy, ensure compliance, maximize dose and consider additional diagnosis Does patient have a symptom complex suggestive of PNDS or GORD?
12 Undem BJ, Carr MJ. Pharmacology of afferent nerve activity. Respir Res 2001; 2: 234–44. 13 Barnes PJ. Neurogenic inﬂammation in the airways. Respir Physiol 2001; 125: 145–54. 14 Karlsson J-A, Fuller RW. Pharmacological regulation of the cough reﬂex. Pulm Pharmacol Ther 1999; 12: 215–28. 15 Fox AJ. Modulation of cough and airway sensory ﬁbres. Pulm Pharmacol Ther 1996; 9: 335–42. 16 Shannon R, Baekey DM, Morris KF, Lindsey BJ. Ventrolateral medullary respiratory network and a model of cough motor pattern generation.
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